Infections due to gram-positive bacteria represent a growing issue, mainly as a result of the increasing number of health-care related infections and of patients with implanted foreign prosthetic materials (i.e. prosthetic heart valves, vascular prostheses, articular prostheses etc.). Pathogens such as Staphylococcus aureus and Enterococcus spp are commonly associated with nosocomial infections, and the rising number of problematic antimicrobial susceptibility patterns adds further complication to the selection of an effective antibiotic strategy. Furthermore, the increasing frequency of infections requiring prolonged antimicrobial treatment and/or a surgical approach in order to remove the infectious focus constitutes a predisposing factor for other health-care related complications. 
Given these premises, the need for a multidisciplinary approach involving specialists in Infectious Diseases, Surgeons of the several specialties of reference (Cardiac surgery, Vascular surgery, Orthopedic surgery, etc.) and all the other professionals required (Cardiologists, Radiologists, Nuclear Radiologists, Microbiologists, etc.) is crucial in order to effectively manage these infectious complications. In this regard, the creation of multidisciplinary teams is pivotal to ensure a synergistic approach for a multi-faceted illness.
A useful tool for the management of these conditions requiring prolonged antimicrobial treatment, and thus a prolonged hospital stay, is the recent development of new  antimicrobial compounds; new molecules with a longer half-life  (long-acting) which allow for extended intervals between doses (up to one week) are promising as they may help in optimizing health-care resource utilization with a decrease length of hospital stay and an improvement in patients’ quality of life. 
This seminar is structured with themed lectures by international experts, followed by an interactive discussion with the audience to generate a debate on the antibiotic and multidisciplinary management of difficult-to-treat gram-positive infections.